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KMID : 1134820000290030513
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 3 p.513 ~ p.517
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Antigenotoxic Effects of Phellinus linteus and Agaricus blazei Murill Extracts
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Ji Jeong-Hwan
Kim Mi-Nam
Chung Cha-Kwon
Ham Seung-Shi
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Abstract
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This study was designed to demonstrate the antigenotoxic potential of methanol extracts from Phellinus linteus and Agaricus blazei Murill against the frequency of micronucleated polychromatic erythrocyte (MNPCE) produced by N-methyl-N’-nitro-N- nitrosoguanidine (MNNG) in vivo. We used the mouse bone marrow test system to measure the effect of single treatment of each samples. Each extract was administered to animals at doses of 10, 20, 40 and 80 mg/kg immediately after injection of MNNG and the exposure time was 36 hours. P. linteus methanol extracts revealed 10.6%, 24.4%, 40.7% and 75.6% of inhibition at doses of 10, 20, 40 and 80 mg/kg, respectively. And P. linteus methanol fractions revealed 81.3%, 78.1%, 75.6%, 72.4% and 63.4% in the presence of ethylacetate, diethylether, butanol, chloroform and aqueous of inhibition at dose of 80 mg/kg. Whereas A. blazei Murill methanol extracts showed 37.4%, 53.7%, 73.2% and 86.2% inhibitory effects, respectively. And A. brazei Murill methanol fractions revealed 86.2%, 81.3%, 78.1%, 69.9% and 61.8% in the presence of diethylether, ethylacetate, chloroform, butanol and aqueous of inhibition at dose of 80 mg/kg. These results showed both mushrooms enhanced antigenotoxic effects.
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KEYWORD
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Phelinus linteus, Agaricus blazei Murill, antigenotoxic
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